Stephen C Graham University of Cambridge

Stephen C Graham University of Cambridge

Dr Stephen Graham

Dr Stephen Graham

Sir Henry Dale Fellow and University Lecturer

Division of Virology, Molecular mechanisms of membrane trafficking and viral infection

Office Phone: +44 (0)1223 336920

Department of Pathology
University of Cambridge
Tennis Court Road

Research themes

Virology:Molecular mechanisms of membrane trafficking and viral infection

Research Interests

The compartmentalisation characteristic of eukaryotic cells presents a logistical dilemma: How do cells ensure components are efficiently delivered to only the correct intracellular compartment? My lab seeks to understand how multiprotein complexes regulate fusion of compartments in the eukaryotic endocytic pathway.

Viruses that seek to exploit the rich environment inside host cells face a similar dilemma: How can they subvert host membrane trafficking to ensure progeny virions efficiently exit infected cells? I am investigating how viruses that acquire double membrane envelopes within cells are trafficked to and fuse with the plasma membrane.

  • Group Members:
    Julia Muenzner, Danielle Owen, Susanna Colaco, Morag Hunter, Chen Gao, Lyudmila Ivanova

Key Publications

  1. A. Albecka, D.J. Owen, L. Ivanova, J. Brun, R. Liman, L. Davies, M.F. Ahmed, S. Colaco, M. Hollinshead, S.C. Graham^ and C.M. Crump^ (2017) Dual function of the pUL7-pUL51 tegument protein complex in HSV-1 infection. Journal of Virology, 81: e02196-16
    doi: 10.1128/JVI.02196-16
  2. J. Muenzner, L.M. Traub, B.T. Kelly^, S.C. Graham^ (2017) Cellular and viral peptides bind multiple sites on the N-terminal domain of clathrin. Traffic, 18: 44–57
    doi: 10.1111/tra.12457
  3. S. Neidel, C. Maluquer de Motes, D.S. Mansur, P. Strnadova, G.L. Smith, S.C. Graham (2015) Vaccinia Virus Protein A49 is an Unexpected Member of the B-cell Lymphoma (Bcl)-2 Protein Family. Journal of Biological Chemistry, 290: 5991–6002
    doi: 10.1074/jbc.M114.624650
  4. B.T. Kelly, S.C. Graham, N. Liska, P.N. Dannhauser, S. Höning, E.J. Ungewickell, D.J. Owen (2014) AP2 controls clathrin polymerization with a membrane-activated switch. Science, 345: 459–463
    doi: 10.1126/science.1254836
  5. S.C. Graham*^, L. Wartosch*, S.R. Gray, E.J. Scourfield, J.E. Deane, J.P. Luzio^, D.J. Owens (2013) Structural basis of Vps33A recruitment to the human HOPS complex by Vps16. Proceedings of the National Academy of Sciences of the USA, 110: 13345–13350
    doi: 10.1073/pnas.1307074110