Phil James Cardiff Metropolitan University

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Phil James Cardiff Metropolitan University

Phil James Cardiff Metropolitan University

​Professor Philip James

Job Title:            Professor of Cardiovascular Metabolism, Associate Dean (Research)
Room No: D211a
Telephone No:  + 44 (0) 2920 417129
Email Address: PJames@cardiffmet.ac.uk

Research

Research Portfolio

I have authored 141 research publications to date the majority as primary or senior author, and present with a current overall H index of 27. This comprises 81 full papers in high-impact, peer-reviewed journals. I have also edited 1 research book and 6 chapters on methodology and Review texts. My work has also been published in the form of abstracts and commentaries (53, counting those in peer-reviewed journals only). The international quality of my outputs is further evidenced by my full inclusion in the Research Excellence Framework (REF) 2014, with four, 4* submissions

I have successfully gained a total research income of £3,262,042 of which £568,500 is currently active research, including a British Heart Foundation Project Grant, a NISCHR funded PhD Scholarship, and a Royal College of Physicians Fellowship (full details provided in cv).

The foundations and principles underpinning my approach to biomedical research were seeded during post-doctoral training and Associate Professor positions (Dartmouth Medical School, USA) where I built in-depth experience with techniques for measurement of oxygen, nitric oxide, and other radical species, and worked under the tutelage of Prof. Harold M Swartz, a pioneer in this research. During this apprenticeship I was awarded The Lubbers Award for outstanding contribution by a young scientist in the field.

I was recruited to Cardiff Medical School in 1999 to a Lectureship and the research opportunities afforded by being an integral part of the newly completed Wales Heart Research Institute. At this time I learnt of the concept that nitric oxide (NO), an important dilator of blood vessels, is not metabolised solely for excretion, but could be recycled from its key metabolites and subsequently utilised at sites remote from its production. I see this as a landmark moment in my research career because interest was sparked which features heavily in my current research. We built a team of scientists and clinicians to test the importance of this phenomenon in humans and soon featured amongst the leading laboratories worldwide in this field. I identified early disturbance in blood NO metabolism in diabetic patients, work that was a significant step in understanding the complex mechanisms contributing to small vessel disease in poorly controlled diabetes. The importance of tissue oxygen in controlling NO metabolism was soon appreciated; first to show release of NO from blood stores influences the venous circulation (with Prof M. Frenneaux, Norwich Medical School), and first to show interchange of NO metabolites across the heart in the human coronary circulation (Dr Vince Paul, St Georges; Dr R. Anderson, Cardiff).