J. A. H. Murray University of Cambridge

J. A. H. Murray University of Cambridge

Dr Andrew J Murray

Dr Andrew J Murray

University Senior Lecturer in Mammalian Physiology

Office Phone: 01223 333863

Websites: http://www.pdn.cam.ac.uk/staff/murray/index.shtml

J. A. H. Murray University of Cambridge, Research Interests

Mitochondrial function in health and disease

My research is concerned with mitochondrial function:

  • how this is altered in metabolic diseases, during development and ageing, and with changes in diet, exercise and oxygen
  • what effects these changes have on physiological performance.

We aim to elucidate the causes of mitochondrial dysfunction and the impact this has on function at the level of the tissue, intact organ and whole body.

Keywords

cardiovascular physiology ; hypoxia ; cardiometabolic disease ; oxidative stress

Key Publications

Most recent publications are listed on PubMed.

Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism. Ashmore T, Roberts LD, Morash AJ, Kotwica AO, Finnerty J, West JA, Murfitt SA, Fernandez BO, Branco C, Cowburn AS, Clarke K, Johnson RS, Feelisch M, Griffin JL, Murray AJ. BMC Biol. 2015 Dec 22;13:110.

Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway. Roberts LD, Ashmore T, Kotwica AO, Murfitt SA, Fernandez BO, Feelisch M, Murray AJ, Griffin JL. Diabetes. 2015 Feb;64(2):471-84.