Frank .D. King University College London

Frank .D. King University College London

Frank .D. King University College London

Professor Frank Kelly

Professor Francis KellyProfessor of Environmental Health
Director, Environmental Research Group
Deputy Director of the MRC-PHE Centre for Environment and Health
Telephone number: +44 (0)20 7848 4004
Email address: frank.kelly@kcl.ac.uk

 

King’s Postal Address:
Analytical & Environmental Sciences Division
King’s College London
4.116B, 4th Floor, Franklin-Wilkins Building
150 Stamford Street
London SE1 9NH

Professor Frank J Kelly BSc, PhD

Professor Frank Kelly holds the chair in Environmental Health at King’s College London, where he is Director of the Analytical & Environmental Sciences Division. His other positions of responsibility are Director of the Environmental Research Group, Director of the NIHR Health Protection Research Unit in Health Impact of Environmental Hazards and Deputy Director of the MRC-PHE Centre for Environment & Health. From these dual positions he is able to combine his two main research interests, namely free radical/antioxidant biochemistry and the impact of atmospheric pollution on human health.  Further details of this activity can be found on the ERG and London Air websites.

In addition to his academic work Frank is past President of the European Society for Free Radical Research and past Chairman of the British Association for Lung Research. He is also involved with providing policy support to the WHO on air pollution issues and is a member of  the Committee on the Medical effects of Air Pollution (COMEAP).

Research

Breathing is obviously an essential activity – but depending on your location (a busy road or industrial location) every breath you take has the potential to introduce dangerous gases and airborne particles to your lungs.

Prof Kelly’s research focuses on how the lung defends itself from these challenges and why, for some of us, these defences sometimes fail. Much of his current work examines the oxidant mechanisms underlying air pollution-induced lung injury.

Prof Kelly is trying to understand how pollutants such as ozone, nitrogen dioxide and tiny traffic-related particles interact with the lung and initiate injury.

As well as conducting studies in healthy volunteers he is particularly interested in how these events differ between healthy subjects and those with pre-existing airways disease such as asthma. The primary focus of these studies relates to the events occurring within the respiratory tract lining fluid (RTLF) compartment of the lung. This thin layer of fluid, which lines the surface of the lung, represents the first and maybe most important line of defence against inspired pollutants. Prof Kelly suspects that oxidant/antioxidant events occurring in the RTLF are pivotal to understanding the impact of air pollution on the lung. Since many respiratory diseases involve inflammation, RTLF antioxidants have also the potential to defend the lung against free radicals released by invading white blood cells.

In collaboration with clinical colleagues at the University of Umea in Sweden, Prof Kelly utilises bronchoscopy and bronchoalveolar lavage procedures to investigate the nature of oxidant/antioxidant interactions occurring in the RTLF compartment. These studies, in combination with cell culture and in vitro approaches, have allowed Prof Kelly and colleagues to develop an understanding of the time-course of events in the airways following oxidative challenge.

These findings have led them to realise the need to obtain a better understanding of how diet and genotype interact to determine an individual’s complement of RTLF antioxidants. Prof Kelly and colleagues have obtained data on the antioxidant defence network within RTLF of healthy individuals and are investigating how diet and genetic background can influence this.

In addition to these chamber-based volunteer studies, Prof Kelly and colleagues are taking advantage of the natural experiments that are taking place in London following the introduction of traffic management schemes such as the Congestion Charging Scheme (CCS) and the Low Emission Zone (LEZ). Both schemes have the potential to influence vehicle emissions and thus air quality in London. With colleagues in Imperial College, St George’s and the London School of Hygiene & Tropical Medicine Prof Kelly is determining if this is the case and if they can demonstrate a health benefit of these traffic intervention schemes.

People

Research Staff

Ms Fatma Amari

Ms Christina Dunster

Dr Esme Purdie

Dr Helen Wood

 

PhD Students

Krystal Godri

Irene Katsaiti

Shukri Modh Aris

Natasa Polak

Winston Lu

Contact us

Switchboard (general enquiries)

Telephone: +44 (0) 20 7836 5454

Postal address

Please be sure to include the recipient’s name and department in the address.

King’s College London
Strand
London
WC2R 2LS
United Kingdom