E.J. Glass University Of Edinburgh UK
Education / Academic qualification
|1981||Doctor of Philosophy (PhD), University of Edinburgh|
“Studies on mononuclear phagocyte receptors”
|1976||Bachelor of Science, University of Edinburgh|
Current Research Interests
Immunogenetics and functional genomics of disease resistance and immune responsiveness traits in livestock species.
My research in a nutshell
My research is focused on understanding how genetics impacts on the way cattle interact with major pathogens of cattle. I am investigating the early events following infection with Mycobacterium bovis, the causal agent of bovine tuberculosis (bTB). This bacterium enters and resides in specific immune cells, macrophages. Although these cells can kill M. bovis, it employs various strategies to grow and survive within these cells. Understanding the molecular mechanisms involved in these interactions would aid in the development of improved vaccines to help control bTB.
Identifying genetic markers which influence the risk of an animal becoming infected with a pathogen such as M. bovis could lead to targeted selection of more resistant cattle. This would be a sustainable and long-term approach to contributing to reducing bTB.
The main aim of the Liz Glass lab is to improve the ability of livestock to withstand infection with pathogens by breeding more disease resistant livestock and by improving vaccine efficacy. The group is focusing on early host-pathogen interactions as these likely determine the outcome of exposure to pathogens and vaccines, leading to protection or pathology. Currently the research team is mainly focusing on bovine tuberculosis (bTB) caused by the bacterium, Mycobacterium bovis, which resides within host bovine macrophages. Approaches include transcriptomics and functional assays to uncover the cellular and molecular pathways induced by infection in vitro. Understanding their relationship to variable outcomes in vivo, could identify novel innate immune correlates of protection and thus aid the design of more effective vaccines. The group is also exploring the genetic basis of variation in the host’s response to infection by locating the genes involved, through SNP based whole genome association studies. Understanding how variation in genes controlling immunity impacts on infection could identify new ways to direct the immune response for more robust host defence.